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run the executables in 64bit mode but will crash
I assume you're still referring to the the 32-bit executables here. What exactly do mean with 64-bit mode for a 32-bit Windows executable then?
Have you tried the 64-bit Windows release of Lix in Wine instead of the 32-bit Windows release of Lix in Wine? 64-bit Windows Lix runs largely well in Wine on Linux. That's my main way to smoke-test for Windows. Do you see 64-bit Lix crash in Wine on macOS?
For more adventures, you can
build Lix natively for macOS.
I don't offer a binary release for Mac yet: I have no Mac myself and haven't looked into cross-compiling from Linux for Mac. Still, Lix is designed to run on most common platforms, and ideally I'd ship Mac binaries with every release.
Virtualizing a full Windows sounds like an extreme measure indeed. For NeoLemmix though, I see few alternatives if Wine fails for the released NeoLemmix executables.
-- Simon