Unfortunately, it's a known bug in current version of DOSBox, sound no longer works when you raise the cycles too high.
What's your machine's specs? I generally don't find it necessary to raise the cycle at all, the game works fine at the default, although levels with many interactive objects does take slightly longer to load.
If it's still too slow on your computer you can try increasing the frame skip, although that does make the animation more jerky since DOSBox isn't updating the screen as frequently as it needs to.