Firefox, because
a) it has adblock and flashblock plugins, among others
b) safari started saving thumbnails - which were so high resolution they might as well have been screenshots - of every webpage I went to and started eating away at my limited harddrive space.
c) IE isn't available for the mac, and it's s*** anyway.
Opera was alright, though, when I tried it, and it became my main browser a couple of times when Firefox refused to work for whatever reason.
I haven't tried Chrome; I don't like the idea of Google having even
more of my personal details. Edit: That, and they don't support older PPC macs, or my version of the OS, anyway... stupid apple introducing blocks to compatibility.

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Also, I've tried the new version of Firefox recently, and they've done the
one thing that made me switch away from Safari in the first place, namely having the stop and refresh functions on a single button. (The reason this annoys me is to do with slow connections and computers - and if you try to stop a page from loading but the computer takes so long to respond that it interprets the click as a refresh, you can be driven up the wall very easily. Java often induces the effect...) The default interface also has the buttons on the right of the address bar instead of on the left next to the back/forward buttons, which I also hate, and the tab bar has moved to above the address bar instead of below it, like Opera and Chrome. And they've taken away the status bar (wtf?). And the bookmark bar has little icons on it. So basically it's an amalgamation of all the interface features I hate, some of which you can't change back. So I'm not going to update to
that if I can help it.